The Resistance story continues to unfurl with protagonist Sergeant Nathan Hale. Having destroyed the London command centre of the invading alien Chimera, Hale returns to the United States where he becomes part of a special programme known as the Sentinels – a secret weapon against the Chimera assault that the US government knows is imminent. When the Chimera launch a full-scale aerial assault on both coasts, Hale and the Sentinels find themselves in the forefront of the counter-attack.